User blog comment:Beast of burden/BIOSHOCK 3: BIG BROTHER/@comment-6024608-20131019121029/@comment-6024608-20131020163508

Well, probably, after 'The Central Council' took over these places they started shutting some of them down (The Little Sister Ophanages kept producing ADAM which was needed to  keep more people from going addiction-crazy). Fontaine's 'Little Brother' programs (whatever they were - if any) may have been discontinued  (that was a couple of months before the Kashmir Incident, at the end of 1958)  Many would simply been 'on the streets'. The Vita-Chamber stuff would have been later. 'Big Brothers' would have been years (~7) later around the time of BS2 (to give them the typical teenager attitudes...).