User blog comment:D.Ryan/Is Sander Cohen dead?/@comment-939754-20100404013814

Bioshock123, it's is extremely likely he can't use Vita-Chambers, considering there isn't even background implication he is related to Ryan. No where does it say he can, and it is still disputed whether it is some plasmid/tonic, or a glitch, that causes him to re-appear when attacking his Masterpiece.

As it stands, he seems he could be dead. As per Deco Devolution, it mentions that by BioShock 2 ' s time, Fort Frolic has flooded. Now, perhaps he is at his apartment at the time, but I don't think his insane mind could abandon the place he holds so dear. I can imagine him going to an airlock into Fort Frolic and drowning himself trying to return.