User blog comment:D.Ryan/Big Brother Enemy Scorecard and Drawing/@comment-1330314-20100812102528

Oh, right. Well, in that case he could be a single character which you could fight several times, like they suggested with the Big Sisters last time. Every time you do something that goes against him (fix something he broke, destroyed his old home, something like that), he could come and try to kill you. He could have this huge health bar, and every time you depleted it to some limit he'd freeze you and escape. If you fight him afterwards, you'll see the gap in his health from the last fight(s).

The main bad guy could be one of the scientists in charge of the Little Brother program. He'd know how to pull his strings and manipulate him into doing his bidding. He could mark you as the "bogeyman" or some other kind of childhood monster and order him to kill you. It could be nice if towards the end the Big Brother turning on him. He doesn't have to join you or return to his sanity, he could just try to kill the guy with you (or do it himself. You could then have to fight the Big Brother pumped up on ADAM).