User blog comment:Charly Cohen/BioShock 4/@comment-70.26.73.88-20131224150018/@comment-75.36.139.222-20131225101049

Isolation is the main plot factor, so doesnt have to be light yeras away just far enough that arrival/departure is restricted (no help coming, and whatever developments of the place falling apart gets contained locally)

Moon or Space station has been discussed before. A 50's theme would allow the nostalgia element (and political environment of Cold War, etc..) so important to these games (and assets they can virtually copy from existing materials)

Atom punk ..