User blog comment:Rapture's Daddy/Would splicing raw ADAM explain Splicer deformities?/@comment-1703246-20100809214746

No, one of Dr Tenenbaum's Audio Diaries explains it (in the Apiary in the Farmer's Market), ADAM is like a benign cancer, destroying native cells with the unstable stem cell versions, it's what makes Plasmids and Gene Tonics enhance the users performance, but if not taken regularly, it also results in mental and physical deformities, they have to take more and more ADAM to stem back the tide, something they didn't realise until it was too late.