User blog comment:GeneralOwnage55/Who would win in a fight?/@comment-1671655-20100122214007

Well, from what I've seen, the Big Sister has similar strengths to Fontaine; Powerful, fast, and has splicer abilities.

Jack is just a human being. Yes, he's spliced up, and has an arsenal of weapons, but he's still a human. I think the Big Sister could be a match for Fontaine.