User blog comment:Charly Cohen/BioShock 4/@comment-217.35.84.11-20130528120207/@comment-121.223.193.192-20130609141024

Space would be interesting, but its used too much nowadays... Underground would be cool too but it might end up being like the movie "CIty of Ember"

I'm think it should be about the start of the maddness when they first found out about ADAM in Rapture and combined the first Little Sister with a ADAM Slug, then something goes wrong and the Little Sister becomes too powerful.

Maybe you could play as someone caught up in the mess of it and have to try escape the area where the chaos is happening or something and you need to make careful moral descisions if you want to get out alive. (Just a summarisation of a idea I have)