User blog comment:LightOfJustice/What is your idea for the next main character in Bioshock 3?/@comment-1703246-20100712224321

I'm thinking it's someone that Dr Tenenbaum had join her, possibly a former Little Sister, possibly not (although it would make genetic damage impossible). She did mention that there were "others she had to help before the city drowned", implying that Bioshock 3 might be a "Same time, different perspective", Like Opposing Force was to Half Life. Seperate yet linked.