User blog comment:Charly Cohen/BioShock 4/@comment-75.138.196.144-20140219022543/@comment-75.36.140.39-20140219165450

Or Ryan coming back after a malfunction (he wasnt actually committing suicide by something went wrong) wants to and tries to rebuild his City and fix things, but someone else is still pushing the ADAM to keep 'their' power (LS still enslaved, etc..). Ryan gets Tenenbaum sent back down (he still has resources on the surface) to get a Cure (to fix all the still ADAM-damaged survivors). Somehow Jack would be a clue to the cure (he survived so much ADAM we pumped into ourselves and because of the way he was created he was largely immune - since he didnt melt down and go insane (much?)).

Ryan overcomes the opponent (hopefully without splicing or becoming a BD), but maybe dying in doing it. In the end, Rapture still lives, but is a retro freakshow and the Surface is still a danger to it, but the ADAM is finally gone.