User blog comment:1onskates/BioShock's Potential/@comment-2040922-20110913223348/@comment-2250991-20110914041348

Don't worry. sometimes, there isn't anybody that'll pay attention to the Blogs. If it makes you feel better, there were some Blogs that I made that nobody bothered commenting.

To answer your question, Infinite will be new to the BioShock universe, while at the same time, share some of its archetypes and gameplay that the first game had. The Plasmid system will be a bit altered with the way Vigors work, especially when there's no ADAM in Columbia, but you can refill Vigors with more of them around the city. It'll be more interactive than the previous games, thanks to multiple AIs that cue at certain moments in the game. And there's also other game mechanics, such as the Sky-line gameplay, and the ability to have Elizabeth use Tears to bring useful items to you. Also, enemies are a bit docile and won't attack you unless you provoke them, which is a similar mechanic to approaching Big Daddies.

As far as sequels go, it's uncertain if BioShock 3 (the one meaning in Rapture, not Infinite) will happen, but Ken Levine had mentioned that until there's a good story and reason for going back to that world, Rapture is done for now. However, Irrational is working on a different BioShock game for Playstation Vita, which will be brand new to the BioShock universe, and will incorporate concept elements that were originally scrapped from BioShock Infinite.